Cannabidiol is an incredible natural resource for supporting health and happiness. The intelligence of this hemp nutrient allows it to act intimately with the human body to support and rejuvenate the physiological systems.
The medicinal history of hemp and cannabis use extends back for millennia. It is only in the last century that the science behind CBD oil and other cannabinoid products has begun to be understood. Over time, CBD oil scientific research has led to the discovery of plant-derived cannabinoids, endogenous cannabinoids, and endogenous cannabinoid receptors.
Internal Cannabinoid Science
The first fascinating feature of CBD oil science is the discovery of the endocannabinoid system. This human and animal network has receptors in virtually every tissue of the brain and body. As scientists were studying the cannabinoid compounds, they managed to track one of these examples to their designated receptor sites. This receptor site was part of a network dubbed the endocannabinoid system. In time, it was revealed that this system also produced endogenous cannabinoids compounds.
CBD scientific studies frequently discuss two endocannabinoids and two endocannabinoid receptors. For endocannabinoids, most of the research has been directed towards AEA and 2-AG. The receptors can simply be labeled CB1 and CB2. There are more of each, but these are the most well-known examples. Endocannabinoids are produced on demand by the body when their activity is needed to create a therapeutic effect or to maintain balance. Cannabinoid receptors can be found on cells all over the body and mind, although their frequency can range depending on the body’s health and functionality. Our internal endocannabinoids can be made and broken down throughout the body.
All of these elements appear throughout the body and nervous system. However, the science of CBD has revealed that their concentrations can vary in different locations. AEA is partial to CB1 receptors and can be often found in the nervous systems. 2-AG has an affinity for CB2 receptors and is usually located in the peripheral body. It is important to stress that each of these endocannabinoids and receptors has essential roles in the entire system.
CBD and The Endocannabinoid System
CBD has a low affinity for CB1 and CB2 receptors. That doesn’t mean that it can’t have massive implications for endocannabinoid activity. Cannabidiol inhibits the FAAH enzyme. This enzyme is responsible for the breakdown of AEA. This inhibition brings about increased levels of circulating AEA. This endocannabinoid, anandamide, has a dominant presence in the nervous system. Anandamide has an affinity for both CB1 and CB2 receptors, but it is preferential to CB1. CB1 activity is closely linked to neuroprotection, mood balance, energy balance, and more. CB2 action can help to stimulate the immune system, anti-inflammation, and counterbalance CB1 activity for balanced health.
Here we are talking about the effects of the endocannabinoid network. CBD is still being researched for its potential benefits in health. The endocannabinoid system has already been determined to play crucial roles in all of these situations. Beyond these endocannabinoid actions, cannabidiol also interacts with TRPV-1 vanilloid pain and 5-HT1A serotonin receptors.
Cannabinoid Administration Methods
There are multiple CBD administration methods, and each of them has a different absorption rate, onset time, and duration. The standard CBD products that we sell include oral edibles, sublingual oils, vaping e-liquids, and topicals.
Oral use of CBD, only eating or swallowing the product, leads to a low bioavailability rate. Cannabidiol, in an isolated form, has difficulty being absorbed by the intestinal membrane. With a carrier oil and the presence of other hemp nutrients, such as in a broad spectrum extraction, cannabidiol can cross this membrane with more efficiency. Oral use of CBD will take 30 to 60 minutes to kick, and can last for 6-8 hours.
Even in a carrier oral, CBD’s absorption rate can be significantly increased. Sublingual application (placing a CBD oil under the tongue and holding for sixty to ninety seconds before swallowing) will increase the absorption rate of cannabidiol, and it will speed up the onset. This administration would provide relief for a 6-8 hour period, like oral use.
Vaping CBD provides the fastest onset. The inhalation of cannabinoids creates an impact in moments, with relaxation hitting in minutes. This method lasts for 2-4 hours. Topical application does not reach the bloodstream like other methods, but its effects are felt quickly within 15 minutes. Creams will last for 4 hours, while a patch could last up to 12 hours.
Cannabidiol Research Implications
The mechanics behind CBD activity have been thoroughly studied over the years, despite onerous regulations in many jurisdictions. Beyond the biological study of the compound, cannabidiol has been the focus of many double-blind studies to determine its efficiency in caring for wellness and health. The promising results for cannabidiol’s therapeutic use began to show up back in the1980s. Over the years, the implications began to be taken seriously, but it was not until the last few years that hemp flower extractions have become mainstream holistic tools.
Now, CBD Infusions is supporting the education of cannabidiol use and supplying our customers with premium CBD products. Feel free to head over to our Dundee shop if you are in the area or check out our online resources. We wish you the best on your journey to health and wellness.
